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Although ligand-receptor pathways are often thought of as linear paths from engagement to transcription/translation, many studies show that enhanced oxidative potential can augment or suppress signaling pathways, including those related to MUC5AC, while more recently, oxidatively driven epigenetic effects on gene transcription have also been reported (2932)

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Studies revealed that the O 2 production by neutrophils (and other phagocytes) not only promotes oxidative stress in the phagocytes but also in adjacent cells in the vessel wall (Dinauer et al., 1990

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