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Description

ROS disrupt the oligomeric state of PRDX2 and thereby enforce dissociation of the TIMELESS-TIPIN complex from the replisome, leading to a reduction in replication fork velocity 51

Experimental Neurology

In a clinical study of elderly patients with chronic fatigue, results indicated that most of the subjects treated with Cordyceps sinensis pure mycelium reported a significant clinical improvement in the areas of fatigue, cold intolerance, dizziness, frequent nocturia, tinnitus, hyposexuality, and amnesia, while no improvement was reported in the placebo group [1719]

Disrupting HDAC4-Ubc9 interactions restores homologous recombination proficiency in hepatocellular carcinoma [72], while targeting USP38-HDAC1 stabilization compromises NHEJ efficiency by suppressing chromatin compaction [6]