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The application of oxamate by inhibiting lactate production can convert tumor-infiltrating lymphocyte and CAR-T cell phenotypes to a more potent state, maximizing tumor-killing effects and improving survival rates in GBM mouse models when combined with CAR-T [169]

G93A-SOD1 epSPC-generated neurospheres exhibited a reactive glial phenotype, as shown by GFAP immunoreactivity that was higher than in cells from age-matched control animals