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Pathway-specific PGSs, targeting acetylcholine, GABA, calcium channel, mitochondria, circadian rhythm, and GSK pathways, are associated with lithium response, but each explains only a small fraction (0.29%1.91%) of the variance

Occasionally, dyschromic patches on sun-exposed regions of the body and features similar to lichen planus pigmentosus may also present as a late manifestation of low-grade prolonged phototoxic reactions [33]

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It ages, loses elasticity, and suffers from oxidative stress and environmental damage