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Description

Senescent fibroblasts and endothelial cells, through the secretion of SASPparticularly PDGF-Apromote an increase in myofibroblast numbers at wound sites, which positively affects wound healing [141]

Moreover, ccontinuous infusion of GLP-1 upregulated islet Pdx-1 gene expression and induced -cell proliferation and neogenesis in rats [58]

The interaction of both sTLRs and sCD14 with other bioactive factors in human milk upregulates and downregulates the action of various TLR-mediated inflammatory responses (60, 61)