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10.1016/j.semcdb.2021.02.006 127 SpinelliJ

Microbiology Sputum culture should be performed at diagnosis to ascertain colonisation and to direct subsequent antibiotic therapy

For instance, elevated ROS may oxidize the highly-conserved, active site Cys residue of mitogen-activated protein kinase phosphatases [106, 107], resulting in persistent activation (phosphorylation) of mitogen-activated protein kinases such as JNK and p38 kinase, contributing to MDMA-induced apoptosis/necrosis