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265,266 When GLP-1 binds to its receptors in the hypothalamus, it activates specific neurons, including those that promote satiety (POMC/CART neurons) and inhibits those that induce hunger (NPY/AgRP neurons), thereby enhancing the feeling of fullness and reducing food intake

26 , 420432.e9 (2019)

Those three residues were highly conserved in different bacteria (Supplementary Fig

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