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Cobalamin deficiency can cause a host of symptoms, including: Tiredness and weakness Nausea Decrease in appetite/weight loss Poor memory and concentration Sore mouth/tongue Numbness/tingling in limbs Vision problems and balance issues Heart palpitations Depression and irritability

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Complementary work has documented activation of the VEGFR2 (Vascular Endothelial Growth Factor Receptor 2) pathway, involved in angiogenesis, along with upregulation of early growth response genes (Egr-1) and the FAK-paxillin transcription factor in studied endothelial cells