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N., Nebert, D

Although ROS generated under physiological conditions are not harmful, and likely play a signaling role, toxic or pathological conditions that lead to an impairment of mitochondrial function can increase the release of ROS

J Mol Cell Cardiol 52(3):660666

These findings came from the 2023 phase 2 clinical trial of retatrutide published in the New England Journal of Medicine, which observed dose-dependent weight loss across multiple dose levels