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Description

Studies have documented decreased mRNA expression of key steroidogenic enzymes, including steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain lyase (P450scc), 17-hydroxysteroid dehydrogenase (17-HSD), and 3-hydroxysteroid dehydrogenase (3-HSD) [49, 50, 70, 145, 153, 176, 177] (Table 4 and Fig