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While the glycolytic glucose metabolism and the mitochondrial oxidation of glycolysis-derived pyruvate and amino acid-derived -keto acids have been extensively studied for astrocytes, more information is warranted to understand the contribution of LDs [189, 190] and proline [70, 257] in the energy metabolism of astrocytes, especially considering the known consequences of alterations in the metabolism of LDs [190, 258] and proline [259] in human neurological diseases

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Overnight cultures were grown in SM media (potassium phosphate-buffered, pH 6.0) with or without lysine (76 mg l 1 ) supplementation and were diluted to OD 600nm = 1 in water, serial diluted and spotted onto SM media (potassium phosphate-buffered, pH 6.0) with or without lysine supplementation and H 2 O 2

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Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation