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Integrative genomic and proteomic analysis of low-dose ionizing irradiation effects on bone marrow stromal microenvironment and on survival of pre-leukemic cells

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P-selectin overexpressed by endothelial injury interacts with its ligand P-selectin glycoprotein ligand-1 (PSGL-1) on almost all leukocytes (63) and the glycoprotein Ib (GPIb) receptor on platelets, which facilitates the attachment of leukocytes and platelets to the injured regions of the endothelium through activation of the PSGL-1 signaling in leukocytes and the GPIb signaling in platelets (64, 65)