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These mediators include the inflammasome complex NOD-like receptor thermal protein domain associated protein 3 (NLRP3), and tumor necrosis factor-alpha (TNF-), which in turn exacerbate the dendritic and synaptic impairments leading to neuronal death and promote AD progression [13,14,15]

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J Pineal Res 31:17

Peptidic natural products are typically sourced by post translational modifications affected upon ribosomally synthesized peptides or as peptides that are assembled by megadalton assembly line-like non ribosomal peptide synthetases (NRPSs) [1, 2]