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Whether sublingual delivery actually produces meaningfully different exposure than oral hasnt been studied in humans

The authors proposed that treatment of these diseases with a combination of levodopa and an inhibitor of O-methyl-transferase may prevent tHcy elevation and oxidative stress (Muller, 2009)

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Such differences include the main glucose transporter (predominantly GLUT1 instead of GLUT2) (7), islet lipid handling (8, 9) and the sensitivity of human and rodent -cells to the toxic effects of LC-SFA (10)