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Several factors, including hypoxia, overload of all-transetinal (atRAL), high intraocular pressure, aging, and iron metabolism imbalance, lead to abnormal accumulation of iron in cells and retinas by affecting the proteins involved in the iron metabolism and homeostasis (Ugarte et al., 2013

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10.1111/j.1528-1167.2008.01840.x Epilepsia

Whilst there is no official contraindication preventing their concurrent use, the evidence supporting additional benefits from this combination remains limited