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Furthermore, our results revealed that l-Carnitine reduced PFOS-mediated autophagy through the suppression of ROS levels, which is supported by the results of another study that revealed that l-Carnitine attenuates autophagy induction by suppressing ROS production in C2C12 cells 39

10.1248/bpb.b19-00805 93

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Two main TMA biosynthetic mechanisms have been described involving a specialized ethyl radical enzyme (Craciun and Balskus, 2012), The first pathway comprises CutC with its activator CutD, utilizing choline as a substrate, while the second involves a two-component Rieske-type oxygenase/reductase system (CntA/B)