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Sfrp5pepD disrupts the Wnt/-catenin signaling pathway by inhibiting the interaction between Axin-1 and -catenin, affecting the interaction between MITF and -catenin

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HIF-1 is constitutively active in egl-9(sa307) mutants, which we use here in an integrated genomic, transcriptomic, and metabolomic approach to obtain a holistic and functional description of HIF activation in an intact animal

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However, notably, 3301 cysteine-mediated redox events were quantified in more than one replicate, with medium CV values ranging from 8.4% to 20.4% (Supplementary Fig