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Description

The role of JNK as an amplification pathway for mitochondrial damage induced by APAP has been extensively investigated using different approaches, from pharmacological inhibition to antisense oligonucleotides-mediated knockdown of Jnk1 and Jnk2 or global Jnk2 deletion in mice (Xie et al., 2015), highlighting the hierarchical relationship between ASK1 and JNK in APAP hepatotoxicity

(PubMed) Stranges S, Marshall JR, Natarajan R, et al

NF-B inhibitor protein (IB) is a protein inhibiting NF-B

Arch Biochem Biophys 621:5462

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