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Pharmacological cancer treatment and mitochondrial health It is generally recognised that all oncological treatments affect several aspects of mitochondrial life cycle and function, with varying degrees of impact depending on the cell type

Google Scholar Grace RF, Bianchi P, van Beers EJ

Moreover, a negative correlation between Hb levels and inflammatory markers was found in poor EPO responders, indicating that the severity of anemia correlates with the state of inflammation (176)

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Introduction Pyruvate Dehydrogenase Complex Function catalyze conversion of pyruvate to acetyl-CoA net reaction pyruvate + NAD + + CoA acetyl-CoA + CO 2 + NADH irreversible Structure 3 enzymes that require 5 cofactors thiamine pyrophosphate (B 1 ) FAD (B 2 ) NAD (B 3 ) CoA (B 5 ) lipoic acid similar to -ketoglutarate dehydrogenase complex Regulation activators of pyruvate dehydrogenase in energy status of the cell NAD+/NADH ratio ADP exercise Ca 2+ insulin inhibited by acetyl-CoA Clinical relevance Overview Pyruvate Dehydrogenase Complex Pyruvate dehydrogenase complex (PDC) is a multi-enzyme complex found in the mitochondria of eukaryotic cells and in the cytoplasm of some bacteria