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First, the zinc atom located at the centre of the active area, which forms coordination bonds with the prospective inhibitor, is considered the most important binding 27,39

On the other hand it was reported that several miRNAs targeting several mRNAs of nuclear-encoded mitochondrial proteins, integrating miRNAs into the landscape of translational regulation of mitochondrial functions such as TCA cycle, production of ROS and glutamine metabolism and mitochondrial fission process (82)

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98 , e13317 (2023)