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The mechanism is that sesamin up regulated CREB gene by activating cAMP/PKA signaling pathway, then up regulated the expression of tyrosinase and MITF, and finally induced melanin synthesis (Jiang et al., 2011)

10.1136/annrheumdis-2015-208709 6

In -thalassemia mice, a modest increase in hepcidin expression limited iron overload, reduced the formation of insoluble membrane-bound globin and ROS, and improved anemia