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Theantioxidantglutathione(GSH)isessential forthecellular detoxificationofreactive oxygen species inbraincells

This process involves includes many mechanisms at nanoscale (gene expression), mesoscale (changes in enzymes, ion channels, cytoskeletal proteins, receptors and secreted molecules) to macroscale (neuropathy) levels with the final common consequence of the lost retinal output to the brain (Figure 1)

Autophagy 19(7):19821996 Yamada N, Karasawa T, Kimura H, Watanabe S, Komada T, Kamata R, Sampilvanjil A et al (2020a) Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

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Sample size was calculated with the help of a biostatistician