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Researchers at Monash University in Australia first isolated the fragment in the late 1990s, hypothesizing it could reproduce the lipolytic (fat-burning) effects of growth hormone without triggering the diabetogenic and growth-promoting side effects [1]

Physiologically, this interplay optimizes adaptive responses to environmental challenges [67]

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Results Histomorphometry reveals distinct differences between osteophytes and the adjacent subchondral bone Osteophytes were visible on the joint surface of the specimens (Brightfield imaging: Fig