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Recently, many other biological factors have been proposed to explain PE including genetic vulnerability 7, 8 , robust cortical representation of the pudendal nerve 9 , disturbances in central serotonergic neurotransmission 10, 11 , and thyroid diseases 12, 13

J Biol Chem 293: 1562015627

In mice, estrogen receptors are predominantly expressed in the SCN shell in females, which regulates the pace of the clock, whereas androgen receptors (AR) are more prevalent in the core in males, rich in vasoactive intestinal peptide (VIP) neurons, which regulate the phase of the clock 70,90,91

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