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Description

From the inward-occluded conformation to the outward-open conformation, TM1b and TM6a move away from taurine/-alanine and P4S (Supplementary Fig

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Any deregulation of these two regulatory processes may affect proper oxygen transport to the tissues

Similar engineered HGF was previously reported by introducing the Genenase I cleavage site 18 , but we chose Factor Xa to achieve more controlled and efficient cleavage