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Adjuvant paclitaxel and trastuzumab for node-negative, HER2positive breast cancer: final 10-year analysis of the open-label, single-arm, phase 2 APT trial

Fact: High dosages mean very little if the delivery system is poor

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SA is bound to Fe 2+ via a terminal carboxyl group in a bidentate fashion (Supplementary Figure 6d) and further interacts with Arg309 through a low-occupancy solvent molecule that occupies the site that is generated by decarboxylation of KG to SA, mimicking the interaction to the NOG oxygen in that complex