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In contrast, TNB-738, a novel inhibitory antibody targeting human CD38 ecto-enzyme, is non-cytotoxic and could be used for indications where depletion of CD38-positive cells is not desired 25

Melatonin has been shown to upregulate the expression of several genes crucial for oocyte maturation and cumulus cell expansion

Abbreviations Used BAL bronchoalveolar lavage CySS cystine DNTB 5,5-dithiobis-(2-nitrobenzoic acid) ELF epithelial lining fluid FAD flavin adenine dinucleotide GPX glutathione peroxidases GR glutathione reductase GRX glutaredoxins GSH glutathione, reduced (thiol) form GSNO nitrosoglutathione GSSG glutathione disulfide GST glutathione-S-transferase H 2 O 2 hydrogen peroxide HPLC high-performance liquid chromatography IL interleukin MetO methionine sulfoxide MMA mild-to-moderate asthma NF-B nuclear factor kappa B NO nitric oxide radical NO 2 nitrite NO 3 nitrate Nrf2 nuclear factor (erythroid-derived 2)-like 2 O 2 superoxide anion ONOOH peroxynitrous acid OONO- peroxynitrite PRX peroxiredoxins RANTES regulated on activation, normal T-cell expressed and secreted RNS reactive nitrogen species ROS reactive oxygen species SA severe asthma -SeH selenocysteine (selenol) residue SeOH selenenic acid SeSG selenenyl sulfide adduct -SG reactive glutathione -SH sulfhydryl SOD superoxide dismutase TGF1 transforming growth factor beta-1 Th2 T helper type 2 TRX thioredoxin Acknowledgment This work was supported in part by RO1 NR012021

Neutrophils (purple) and macrophages (green) trigger an initial acute inflammatory response, phagocytosing dying endometriotic cells and tissue debris

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