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To further evaluate the adaptability of the AR-AST system, the test range was expanded to include three microorganisms with distinct characteristics: Lactobacillus plantarum (Gram-positive bacillus, facultative anaerobe), Micrococcus luteus (Gram-positive coccus, aerobic), and Klebsiella aerogenes (Gram-negative, encapsulated pathogen)

Policy and governance gaps include fragmented state-level legislation, weak institutional coordination, insufficient funding, and low-cost recovery, particularly in agriculture, where farmers cannot afford treated wastewater 147,148

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Common Side Effects: The most frequent side effects reported during the first week include nausea, vomiting, diarrhea, constipation, and abdominal discomfort

In support, a 2004 clinical trial by Karl Mann reported a 36.1% abstinence rate with acamprosate, compared to 23.4% with placebo, stating its role in relapse prevention when combined with behavioral therapy