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Further studies have found that LSH can increase the expression of GINS4 by stabilizing its post-transcriptional mRNA level, thus promoting the progression of lung cancer [122]

In the external cohort high-risk tumors, there was increased recruitment/infiltration of granulocytic populations (including neutrophils/eosinophils) and upregulation of proliferative/cell-cycle and metabolic programs (E2F targets, glycolytic metabolism, G2/M checkpoint) ( Further studies are warranted to better validate and classify gene expression pathways that are dysregulated in TDLN with metastasis, which may provide novel targets of therapy

Another important element in human GCL gene promoters that responds to electrophiles in cells and increases gene expression is the EpRE or electrophile response element (Rushmore et al., 1991

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