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Although urine, stool, or volatile samples can be collected in a non-invasive way, the time of elimination has an impact on the degradation of the microbial products, which may have an impact on the analysis (79)

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Additionally, the composition of the protein corona, particularly enrichment with immunoglobulins or opsonins, enhances immune recognition and retention within splenic tissues [262]

Consequently, the results should be considered exploratory in nature and as this trial focused on CR prior to living kidney donations, the transferability on kidney transplantations of elderly, multimorbid patients or transplantations of deceased donors remains scarce