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Cryo-EM data processing All data for both wild-type rabbit RyR1 and R615C pig RyR1 were processed using Cryosparc 4.4.1

10.1074/jbc.M114.606731 19 ChenZ.GriffinI

Acknowledgements L.B

10.1002/14651858.CD000467.pub2 130 RobertJ

528 Current clinical trials targeting the ATXLPALPAR axis The growing preclinical support for targeting LPA signaling has catalyzed the clinical development of both LPAR antagonists and ATX inhibitors