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& Gylfe, E

Al Ameen J Med Sci 2008;1:20-31

In plants, glutathione fulfills a broad range of essential functions including detoxification of heavy metals and xenobiotics and serving as an electron donating cofactor in biochemical reactions (Cobbett and Goldsbrough, E GSH depends on the absolute glutathione concentration and the ratio of [GSH]:[GSSG] (Meyer and Hell, E GSH is assumed to affect the glutathionylation status of proteins which is an important means of regulating protein activity (Michelet et al., Conditions of environmental challenge are frequently considered to cause the generation of oxidants in the form of reactive oxygen species (ROS) (Apel and Hirt, E GSH caused by a transient draw of electrons from the glutathione redox buffer for oxidant detoxification and coupling of E GSH to target proteins thus may result in altered protein function and hence pronounced metabolic and developmental consequences for individual cells and the whole organism

In a healthy individual, the body's antioxidant reservesled by glutathionequickly sweep in to neutralize these free radicals once the infection clears

Meanwhile, ATP detection assays confirmed that the ATP level in GGCT-knockdown cells was significantly reduced and rescued in sodium pyruvate or JX06 treatment groups (Fig