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Guo Lei, orcid.org/0009-0006-4877-5288 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Many P450 enzymes are subject to genetic polymorphism in which some people are endowed with robust metabolic activity (so-called rapid metabolizers) and others have none at all

From a biological standpoint, TfR1 by also binding hemeHPX acts as a scavenger receptor recognizing an array of structurally diverse endogenous proteins, some with key roles in maintaining the cell and whole-body homeostasis of both heme and its iron