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After this initial study, several spirodioxyselenuranes such as have been reported in the literature [48, 49, 50]

Gene therapy vectors can be either viral [commonly adeno-associated viruses (AAVs) and lentiviruses (LVs)] or non-viral (typically naked plasmid DNA or in complex with cationic lipids or polymers) (O'Connor and Boulis, 2015)

score 3, 26-49% involvement

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Melatonin prevents free radical formation due to the interaction between B-amyloid peptides and metal ions [Al (Iii), Zn (Ii), Cu (Ii), Mn (Ii), Fe (Ii)