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The other redox system with similar roles is the thioredoxin system, comprised of thioredoxin and thioredoxin reductase ( Because DNA is an add-on to RNA biosynthesis, deoxyribonucleotides can only be synthesized via the reduction of ribonucleotides by RNR, a process which is unsustainable without the participation of one or both of the thioredoxin and glutaredoxin systems

doi: 10.1016/S2213-2600(20)30161-2 219 PoeF

Peres RAS, Silva-Aguiar RP, Teixeira DE, Peruchetti DB, Alves SAS, Leal ABC et al (2023) Gold nanoparticles reduce tubule-interstitial injury and proteinuria in a murine model of subclinical acute kidney injury