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On the other hand, in developmental or angiogenesis-driven contexts (as seen in the VHL knockout), HIF-1s primary contribution is indirect promotion by stimulating angiogenesis (e.g., via the HIF-1/VEGF axis), which provides the essential vascular supply for bone formation

104 Medications such as cyclosporine A, bosentan, oral contraceptives, and cyclosporine have been reported to inhibit ABC transporter BSEP or MDR3 function and lead to cholestatic patterns that present as drug-induced liver injury

EMT, which confers metastatic properties to tumor cells by enhancing their invasiveness, facilitating tissue invasion, and enabling distant organ colonization, has emerged as a key regulator of BC metastasis