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RTAs often lack target engagement biomarkers or companion diagnostics, making it difficult to confirm whether they reach and modulate the intended ferroptotic pathways in vivo

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[54] In HepG2 cell lines, eugenol protects human liver HepG2 cells from H 2 O 2 -induced oxidative hepatotoxicity by maintaining ROS homeostasis, increasing IL-10 levels, and upregulating cytochrome gene expression