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Metronidazole resistance mechanisms Resistance to metronidazole (Mtz) has shown to limit the effectiveness of Mtz containing regimens [98, 99]

We have chosen prpTDP-43 A315T mice for our analyses, because this mouse model of TDP-43 pathology was generated based on the A315T mutation detected in the TARDP gene of ALS patients, who had TDP-43 pathology in their cortex 19 , and because the mouse model strictly recapitulated many aspects of the disease, including progressive CSMN degeneration 16

Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, et al

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Membrane modification strategies include covalent conjugation methods, such as bioconjugation and click chemistry reactions, as well as non-covalent approaches like multivalent electrostatic interactions or receptor-ligand binding