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Mild adverse events were similar between treatment and placebo groups, including headache, fatigue, and gastrointestinal symptoms

Diet may also help

Thats a massive gap

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It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number