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Meanwhile, MR can also downregulate genes involved in an inflammatory response and immune cell infiltration, such as chemokine receptor (CCRs), chemokine ligand 7 (CCL7), IL-1, IL-6, IFN-, and TNF-

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In regards to its effect on mitochondria, clinical studies have shown that it can stimulate mitochondrial biogenesis, leading to an increase in the number and function of mitochondria within cells (Yue et al., 2022)

However, after long-term intake of a dosage of 1 gram or more, symptoms such as nausea, vomiting, and diarrhea have been observed, and in extremely rare cases, liver damage may also occur (77)