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Since many of the mechanisms that underlie CIPN overlap, they may reinforce each other

4.1 Neurotoxic models In MPTP models, elevated levels of ACSL4 and elevated iron levels coexist with ferroptosis (183, 184)

However, bottlenecks such as immunosenescence and target heterogeneity still need to be overcome

& Schatzberg, A

Gjermeni E, Kirstein AS, Kolbig F, Kirchhof M, Bundalian L, Katzmann JL, Laufs U, Blher M, Garten A, Le Duc D (2021) ObesityAn update on the Basic Pathophysiology and Review of recent therapeutic advances