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With aging, multiple structural and functional alterations such as decreased cerebrovascular pulsatility, reduced aquaporin-4 polarization on astrocyte end feet, and impaired perivascular cerebrospinal fluid exchange significantly reduce glymphatic efficiency

Furthermore, curcumins antioxidant action protects oral mucosal cells from therapy-induced oxidative stress, and its anti-microbial effect may help prevent secondary infections of ulcerated mucosa (Amatto et al., 2025)

Zhang, L.-J

erinaceus on the quality of murine gut microbiota and found a change in the relative abundance of different bacteria depending on the age of the mice used for the microbiota analysis