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In the lysosome, the opposite reaction occursacid hydrolase enzymes carry out hydrolysis reactions, splitting a water molecule each time a monomer is removed from the chain

10.1113/jphysiol.1950.sp004483 29 de LeceaL.CriadoJ

Trained immunity is initiated in hematopoietic stem cells (HSCs) in the bone marrow

It is proposed that the dimeric KEAP1 captures NRF2 first through the ETGE motif, which has 100-fold more affinity to KEAP1, followed by DLG motif docking onto the other Kelch repeat domain