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plantarum can improve lipid oxidation by increasing the mRNA expression of lipid oxidation genes, including CPT1, ACOX1, and MCAD, and reduce lipid synthesis by activating the SIRT1-PGC-1 alpha pathway, leading to reduction of fat accumulation (Kwon et al., 2020)

DECLARATION OF INTEREST: The authors declare that they have no conflicts of interest

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Sound is also embarking on a Phase II study of SPI-1005 to prevent the ototoxicity, or drug-induced hearing loss, that affects people like Hirko

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