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The growing size of the literature highlighting the impact of research methodologies on quantification of blood-based biological analytes further supports the need for standardized research techniques when it comes to blood-based biomarker collection, preparation, and storage

10.3389/fphar.2022.1066244 17 CrawfordR

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Given the importance of the cofactor in energy metabolism, NAD + is especially important in mitochondrial function, and in fact both NAD + and mitochondria are concentrated in energetically demanding tissues 10,11,12

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