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Indeed, direct tests revealed a lack of input specificity of synaptic changes in CA1 inhibitory neurons (McMahon and Kauer, Thus, initial studies demonstrate that CA1 interneurons can express long-term synaptic plasticity, which is calcium-dependent (Cowan et al., 2001) but not input-specific (McMahon and Kauer, 2+ imaging has demonstrated that synaptically induced rises of [Ca 2+ ] i in aspiny dendrites do not spread much but are kept local by interneuron-specific mechanisms (Goldberg et al., Box 1 and below in the sections on calcium signals and heterosynaptic plasticity

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The results of the study summarized below are presented in more detail in a comprehensive review of the literature, several issue briefs, and this final report ( II

425,426 Additionally, IgG, IgM, and IgA autoantibodies against HSP60, HSP70, and HSP90 are significantly elevated in RA patients