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Clinicians should still be alert to any new arrhythmic symptoms in patients on QLQX, especially if also on digoxin or other inotropes

In accordance with this, the division of chemokines into pro- and anti-inflammatory factors seems to be too simplified and gives rise to contradicting opinions regarding the neuroprotective and neurodegenerative functions of chemokines [29]

To assess its safety for therapeutic use, its cytotoxicity was evaluated in RAW264.7 and human leukocytes, including peripheral blood mononuclear (PBMCs) and polymorphonuclear leukocytes (PMNs) cells

Animal blood is a rich source of proteins and has been widely used as a food ingredient in Asia, Africa, and Europe 18

Notably, fructose metabolism synergistically amplifies this metabolic reprogramming by bypassing EMP rate-limiting steps (e.g., phosphofructokinase (PFK)) and enhancing nicotinamide adenine dinucleotide phosphate (NADPH)-mediated redox buffering capacity, thereby exacerbating CRC aggressiveness and positioning ALDOB inhibition as a therapeutic vulnerability [6, 7]