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In the long-term studies conducted by Khavinson and his team, subjects followed for up to 15 years showed no significant toxicity or negative outcomes attributable to epithalon use

Additionally, staying well-hydrated is crucial

Its antioxidant effects and anti-inflammatory and anti-metastatic potential play an essential role in this process, improving intracellular communication

As an occlusive, it forms a protective layer on the skin that locks in moisture and prevents transepidermal water loss (TEWL)

Topical use typically requires 4-8 weeks of consistent application before changes become visible, with maximum benefits at 3-6 months