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10.1128/mSphere.01044-20 mSphere 26 ChiuT

Xie Y, Guan Q, Guo J, Chen Y, Yin Y, Han X

The pronounced accumulation of glycogen, with and without SER-proliferation, in BH pushes the remaining organelles to peripheral and paranuclear parts of the cytoplasm, leading to a dislocation and relative reduction of the RER and mitochondria, possibly contributing to the miscommunication which has been proposed as an early and causal trigger of hepatic insulin resistance and steatosis