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Position B building blocks (reactants) and B-tags: R1-P1-QC1-V1-T1-QC3-M1-V2-D1-V2-P3-V2-S1-V1 576 position B building blocks (reactants) were used Position C building blocks (reactants) and C-tags: (R1/R2/R3)-P1-QC1-V1-T1-QC3-M1-V2-D2-V2-P3-V2-S1-V1 96 isocyanate building blocks (reactants) were used 96 sulfonoyl building blocks (reactants) were used 384 acylation building blocks (reactants) were used Position D building blocks (reactants) and D-tags: (R1/R3/R4/R5)-P1-OC1-V1-T1-QC3-M1-V2-P3-V2-D1-V2 96 aldehyde building blocks (reactants) were used 96 sulfonoyl building blocks (reactants) were used 96 halogenated heteroaromatic building blocks (reactants) were used 96 acylation building blocks (reactants) were used 96 isocyanate building blocks (reactants) were used The library was screened using unspecific elution (example 7), identifiers were amplified and analyzed by ultra high-throughput sequencing